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Based on the studies reviewed, the role of GLP-1 RAs may be for patients who have optimized a basal insulin regimen and are 0.5% to 1.5% away from achieving their A1C goal

The approval is based on data from the SOUL trial of 9,650 patients and showed a 14 % relative risk reduction in MACE for the 14 mg dose

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Certain Medications: Long-term use of certain medications such as metformin (for diabetes) or acid-reducing drugs (PPIs, antacids) can cause deficiency 2

BPC 157 is a peptide derived from human gastric juice, being researched for its possible regenerative effects in healing tissues and reducing inflammation

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